一个新的3D生物Ink用于Polyjet 3D印刷药丸-3D打印行业 - 必威官网登陆,betway必威手机版登录,betway体育客户端betway体育客户端

研究ers at the University of California in Los Angeles (UCLA) have developed a viable bioink for 3D printed pills.

如在Maastricht的3D医疗博览会上看到的，3D印刷制药是一项相对较新的企业，但据信具有巨大的潜力，可以创新自构想以来一直保持不变的行业。

Evolution of pharmaceutical products in comparison to the telecommunications industry. Slide by Professor Jukka Rantanen from “Designing compartmental pharmaceutical products based on 3D printing” at the 3D Medical Expo 2017. Photo by Beau Jackson for 3D Printing Industry

个性化医疗保健

当前药物的明显缺点是，它不考虑一个人的特定基因组成或血液含量。由于每个人的基因组都是独一无二的，因此人体吸收药物的方式也随人而异。

Referencing figures published by Nature in 2015, the paper用于水亲水药物的喷墨3D药物的光能生物互联州“the top 10 highest grossing medications only have a positive therapeutic effect in 4–25 percent of the patients that take them”.

美国十大药物的功效。Graphic from — 美国十大药物的功效。来自“个性化医学：单人试验的时间”的图形
Nicholas J. Schork

3D printed pill production

In this study, Giovanny Acosta-Vélez, Chase Linsley, Madison Craig and Benjamin Wu favour the inkjet technique over other 3D printing technologies for its speed and ability to print at room temperature. The temperate environment ensures that active pharmaceutical ingredients (APIs) aren’t damaged in the process, and speed is of course preferable for mass production.

The 3D printable bioink from UCLA is made from hyaluronic acid – a key ingredient in skin, connective tissues and the nervous system. A photoinitator is added to the acid so that it solidifies when in contact with light. This mixture is used to fill preformed tablets displaying the properties of an atypical oral tablet.

A，B图表预制药的机械强度。C空的预制平板电脑。图像和照片通过：Benjamin M. Wu等。

然后将透明质酸与ropinirole HCl一起扎根 - 一种通常用于治疗与帕金森氏病有关的肌肉问题的兴奋剂。ropinirole HCl被选为其亲水功能的API；使其在溶解后可靠地测量水溶性。然后，通过压电喷嘴来调节API的沉积。

Droplet formation of Ropinirole Hcl from the piezoelectric nozzle. Photo via: Benjamin M. Wu et al.

Does it work?

After curing, the researchers measure the dissolution rate of the bioink Ropinirole Hcl pills in an acidic substance used to mimic stomach contents. Within the first 15 minutes of tests 60% of the tablet’s contents were released. After another 15 minutes, a further 20% was released, as shown in the graph below.

Measured release of Ropinirole Hcl from the fabricated tablet. Image via: Benjamin M. Wu et al.

在溶解一个小时后，观察到药物释放的峰值，之后丢失了少数比例（约4％）。

PolyJet 3D打印的未来

As a light-reactive ink, the Ropinirole Hcl hyaluronic acid becomes a potential candidate for use in PolyJet 3D printing. As of 2011 Stratasys own the patents to PolyJet technology which combines inject printing with photocuring to make 3D objects.

麻省理工学院的科学家和艺术家Neri Oxman使用Polyjet技术来生产Wanderers: An Astrobiological Explorationcollection of futuristic “wearable skins”.

Neri Oxman的Al Qamar。照片通过：Stratasys — 来自流浪者的Al Qamar：Neri Oxman的天文学探索。照片通过：Stratasys

改善药品和多喷气工艺之间的翻译可能意味着片剂完全可以通过3D打印来生产，而不是使用预制的外壳。这种开发将建立3D打印作为药物生产的可行方法。

These findings published in the Open Access Journal for生物工程from Swiss publishers MDPI (Multidisciplinary Digital Publishing Institute), are the collaborative effort of specialists from the Department of Chemical and Biomolecular Engineering, the Department of Bioengineering, and the Division of Advanced Prosthodontics and the Weintraub Center for Reconstructive Biotechnology.

We will be releasing our shortlist of nominees for the first annual 3D Priniting Industry Awards on 20th February.To ensure your company makes a spot, you can submit your nomination here.

Featured image shows a collection of colored pills, photo by v1ctor on flickr