Glass, electronics, chemicals, and ceramics manufacturerAGC Inc.已经开发了一种生物相容性的非蛋白毒性氨基丙烯酸酯丙烯酸酯低聚物，可以将3D印刷到超现实的患者特异性器官模型中。
With its new oligomer, AGC Inc. has managed to design a material that features a low storage modulus without using plasticizers. As a result, ‘U-FINE LD-301’ can be used as a basis for non-cytotoxic stereolithography (SLA) or Digital Light Processing (DLP) 3D printing resins that are less susceptible to dimensional instability or bleeding issues.
实际上，该公司希望在医学界中采用其可拉伸的新材料，作为3D印刷，具有令人难以置信的寿命，特定于患者的解剖模型，并具有广泛的临床培训应用。
AGC Inc.的产品开发工程师Nikhil Mishra解释说：“我们已经专门设计了该材料，专门用于器官建模。它是生物相容性的，ISO-10993：5批准。它还具有低储存模量，玻璃过渡温度和收缩率。”
A new SLA/DLP resin base material
尽管特定于患者的临床模型的添加剂制造绝不是医学界闻所未闻的，并且有很多用例可以支持这一点，但该过程仍然面临挑战。为了改善其柔软度，许多树脂包括影响其生物相容性和尺寸稳定性的增塑剂。
To get around these issues, AGC Inc. has come up with a new material formulation, which it has managed to make plasticizer-free by focusing on a few integral properties: elastic modulus, glass transition temperature (Tg), shrinkage rate, and viscosity.
The company chose to focus on developing a material with a tunable stiffness due to each organ’s differing elastic modulus. Soft organs like kidneys, hearts, and intestines, for instance, have an elastic modulus of around 10 ~ 40 kPa. In order to 3D print an accurate model, it’s therefore essential to have a resin that enables the creation of good interlayer joints and offers high dimensional stability.
AGC Inc.has also found that minimizing resin shrinkage and viscosity is vital to ensuring print accuracy while reducing any risk of brittleness. As a result, LD-301 is designed to yield resins with a low viscosity, stiffness and storage modulus.
Targeting clinical model 3D printing
According to AGC Inc, LD-301’s novelty lies in its high molecular weight, as well as its mono functionality, low cross-linking and biocompatibility properties, which make it ideal for formulating biocompatible DLP and SLA resins. In fact, during ISO cytotoxicity testing, a cured version of the company’s material is said to have achieved higher than 70% cell viability, and it was found to have no significant impact on the formation of cell colonies.
在休息时的伸长率方面，固化的LD-301也显示出380％的高伸长率。更重要的是，低聚物倾向于具有较高的粘度，但是由于材料的独特分子结构（将其掺入稀释液）中，它具有较低的粘度，以使其成为可打印树脂的更好基础。
Together, AGC Inc. says these properties mean the oligomer is ideal for creating resins that can be turned into realistic anatomical models, with surgical education and planning applications. As the material has shown the capability to resist repeated compressions and return to its initial shape, it’s believed that LD-301 could be used for insoles as well, though it’s primarily being marketed as a medical modeling tool.
Those interested in finding out more about the material or placing an order cancontact AGC Inc. directly for a quote.
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Featured image shows a set of prototype anatomical models and lattice parts 3D printed from U-FINE LD-301. Image via AGC Inc.
