研究人员圣地亚哥大学，，，，MERLN InstituteUniversity College London(UCL) and UCL spin-outFabRx，已经提出了七秒钟内的3D打印平板电脑的方法。
与普通的增值税光聚合过程相反，可用于逐层打印药丸，该团队的体积打印方法能够单次运行中固化完整的树脂。科学家们说，他们的技术有可能提高生产自定义药物的速度，这是一个USP，这对于使最终用途的临床3D打印可能至关重要。
该项目背后的UCL科学家之一Alvaro Goyanes：“这确实可能是制药行业的游戏改变者。”告诉我报纸。“个性化的3D印刷药物正在快速发展。他们开始到达诊所进行试验，在最好的情况下，它们可以在三到五年内用于卫生服务。”
FabRX的定制药物驱动器
自2016年以来Apreciaestablished itself as an early leader in additive manufactured medicine with the launch of fast-dissolving Spiritam, the第一个FDA批准的3D打印药物，可以公平地说，这项技术已经飞跃。
例如，到2020年，巴基斯坦的研究人员已经证明了3D印刷antibiotics with optimized drug-release rates，，，，via fused deposition modeling (FDM) technology and precise infill control. Earlier that year, a team based at圣约翰大学也采取了类似的方法3D printing egg-shaped capsules设计是很难被那些设法粉碎g to abuse prescribed opioids.
最近，FabRX本身也在量身定制的医学领域取得了进步，开发了一种选择性激光烧结（SLS）的方法braille-patterned printlets对于视力障碍，以及启动其M3DIMAKER系统。
该机器被销售为“个性化药物的第一台制药3D打印机”，该机器具有多鼻嘴的设置，可让用户切换头并从FDM转换为直接粉末挤出生产。该初创企业还夸耀该系统受到软件的支持，该软件允许其按需创建规定的药丸，但是这种进度并没有停止其技术的迭代。
In fact, working with colleagues at Universidade de Santiago de Compostela and UCL late last year, FabRx managed to develop its own智能手机驱动的平板电脑3D打印机。该团队的修订设置围绕修改后的M3Dimaker建造，被证明能够生产自定义的血液胶囊，并认为当时可以用来改善对处方药的机会。
增值税聚合的速度限制
因此，鉴于FabRX在具有自定义释放曲线，形状和尺寸的3D打印药物中相对成功的记录，为什么它不设法在药品领域获得更大的吸引力？好吧，除了获得监管机构批准和通过相关测试程序等问题外，以这种方式采用3D打印的商业缺点：吞吐量。
根据UCL领导的团队的说法，“现有的3D打印技术无法为快速节奏的临床环境中按需生产药物所需的速度。”然而，科学家补充说，在聚合以治愈树脂质量的情况下发生的体积打印“利用阈值行为”，因此可以为此提供解决方案。
Now, building on the work carried out in their previous study, the researchers have found a way of putting this approach into practice, by manipulating light in such a controlled way, that it can solidify vats of resin simultaneously. This is said to have been achieved by tweaking the intensity of emitted rays and applying them at various angles, until the full mass of material can be polymerized in one go.
体积3D打印进程
During their study, the researchers deployed a modified 3D printer to assess the efficacy of their revised approach, and produce tablets from six different photoinitiator-loaded resins, with paracetamol being used as a model drug. Initial results from these tests showed that the team were able to produce tablets with tunable drug release profiles, at a rate of anything from 7 to 17 seconds per pill.
With further development, the scientists say that their approach could be used to create ‘polypills’ at pace, the likes of which incorporate tailored doses or multiple medications, but tend to come with longer lead times. One application the technology is currently reportedly being trialed in, involves 3D printing cancer therapy and anti-side-effect drugs inside the same pill at a French hospital.
“To reduce the risk of recurrence, many women with early-stage breast cancer are treated with hormone therapy for five years, often with additional treatments to manage side effects,” Maxime Annereau, theGustave Roussy领导该项目的医院药剂师向I报纸解释了。“将所有这些治疗方法都带到带有个性化剂量的单个3D印刷平板电脑中，应该使完成治疗更容易。”
该技术的另一个潜在应用是为孩子们生产更多开胃药物，尤其是考虑到伦敦的Great Ormond Street Children’s Hospital据说正在权衡其药房安装3D打印机，那里的专家团队认为，将来该技术可能会成为必不可少的套件。
“我已经希望在GOSH的药房里放一台3D打印机，以支持使用3D药物的试验，”大奥蒙德街儿童医院的首席药剂师史蒂夫·汤姆林（Steve Tomlin）也告诉《我报纸》。“了解人们对药物反应（药物基因组学）的遗传差异的知识意味着，我们知道，对于许多药物而言，一种尺寸并不适合全部。”
研究人员的发现在其论文中详细介绍了“体积3D打印用于快速生产药物。” The study was co-authored by Lucía Rodríguez-Pombo, Xiaoyan Xu, Alejandro Seijo-Rabina, Jun Jie Ong, Carmen Alvarez-Lorenzo, Carlos Rial, Daniel Nieto, Simon Gaisford, Abdul W. Basit and Alvaro Goyanes.
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特色图显示了一个图表，描绘了团队方法背后的方法。通过UCL图像。
