AtCharité–Universitätsmedizin Berlin, “Europe’s largest University clinic,” researchers are working to prove that, in specific cases, 3D printed titanium-mesh scaffolds offer a better alternative to conventional bone-grafting techniques using a patient’s own bone.
当治疗由四肢重大创伤引起的大骨缺损时，该处理尤其有效。除了无与伦比的强度外，3D印刷钛植入物可以是旨在适应任何伤害。用复杂的内几何形状制成in a number of cases,事实证明，这种植入物在鼓励鼓励方面更有效in-growth of bone和血管结构对于患者的全部康复至关重要。
为了证明他们的假设，Charité研究人员成功地使用了3D印刷的钛型支架，成功地进行了一项大型动物研究，其中有27只绵羊。然后，该研究转到了19例人类患者的临床前试验。科学翻译医学has published the results.
Mechanically and biologically optimised meshes
The titanium-mesh scaffolds in the Charité study were3D由Depuy合成使用金属激光烧结过程。
The implants were designed with a honeycomb-like structure. By altering the strut diameter of the honeycomb, researchers could create a stiffer implant and maximize support.
该团队还为植入物试验了两种增强机制。屏蔽板和锁定压缩板（LCP），如下图所示。
手术后24周，将钛型支架植入绵羊时被证明“增强骨再生”。
As a result, the decision was made to move to a pre-clinical trail with human patients.
Trial and error
Each of the pre-clinical implants were made to patient-specific requirements. Perhaps critically though, the implants were not mechanobiologically optimized in the same way they were with sheep.
Of the 19 diverse patients selected for the study, two returned with negative bone in-growth on the implants. Nevertheless, the “study supports the hypothesis that endogenous bone defect regeneration within 3D Ti-mesh scaffolds can be promoted by minimizing the scaffold mechanical stiffness.” And bone regeneration through mechanobiological optimization was enhanced in the treatment of sheep.
完整的详细信息可以在网上在纸上找到“机械生物学优化的3D钛 - 网状支架可增强绵羊关键节段缺陷中的骨再生。”
这项研究由Anne-Marie Pobloth，Sara Checa，Hajar Razi，Ansgar Petersen，James C. Weaver，Katharina Schmidt-Bleek，Markus Windolf，Andrasá合着。Tatai，Claudia P. Roth，Klaus-Dieter Schaser，Georg N. Duda和Philipp Schwabe。
这项工作由Charité -Universitätsmedizin柏林与Max Planck胶体和界面，WYSS研究所，AO研究所达沃斯和德累斯顿技术大学合作。
在这里第二届年度3D印刷行业奖中提名2017年最佳研究团队。
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特色图显示了Charité在手术后各个阶段改进的3D钛植入物的证据。通过科学翻译医学的图像
