旧金山生物技术公司Prellis Biologics已成功筹集了870万美元，以推进其全息3D生物打印平台。专业技术资本公司领导的A系列投资Khosla冒险，这一轮由种子贡献者加入真正的冒险andIndie Bio。
成功的筹款是在公司的许多发展之后，包括最近在活动物模型中对3D生物打印细胞进行临床前实验。Khosla Ventures的负责人Alex Morgan博士的创建雄心勃勃的景象说：“ Prellis的光学技术为设计这些较大的组织提供了必要的脚手架。”
“With our investment in Prellis we’re supporting an initiative that will ultimately produce a functioning lobe of the lung, or even a kidney, to be used in addressing an enormous unmet global need.”
可行的人造血管组织的旅程
Prellis Biologics成立于2016年，是一种基于激光的生物打印方法的开发商，称为全息3D打印。该方法能够产生小于0.5微米的特征大小。高速也是针对性的，以防止材料基质内的活细胞恶化。在基本水平上，该技术可以在5毫秒的光照曝光范围内治愈液体。
Prellis’ current aims are to develop holographic 3D printing to a stage where it can quickly and precisely fabricate vascular tissue for organs. In one of the company’s most recent announcements Dr. Melanie Matheu, company co-founder and CEO, explained that the “ultimate goal” is to 3D print “the entire vascular system of akidney in 12 hours or less。”
In a rudimentary step towards this ambitious aim, the company has so far launched its Vascular Tissue Blanks product. Vascular Tissue Blanks are essentially scaffolds used to culture live cells. Recently, vascular tissues made from these scaffolds were transplanted for the first time in a live animal model at Stanford University. Only 200,00 cells, compared to 2 million and more for typical tumor studies, showed capable of achieving full tumor engraftment and vascularization. “A breakthrough like this opens the door to studying rare human tumors and complex human tumor immune system reactions,” explains Dr. Matheu. “It has the potential to significantly reduce overall animal use and speed up drug discovery efforts.”
Khosla的3D打印投资组合
The capital investment fund of Indian American billionaire businessman Vinod Khosla, Khosla Ventures is interested in early stage companies in high tech sectors. As such, the company has contributed to the funding of several other 3D printing related companies. In late 2018, the company invested in the$140 million Series E美国私人航空制造商的融资火箭实验室。Prior to that, 3D printed composite specialistarevobenefited from its backing in a$12.5 million financing round与其他两个政党。该基金也有投资于金属3D打印机developer数字合金在过去。
Matheu博士说：“ Khosla Ventures是支持我们融合深技术和尖端再生医学的理想投资者。”
“有了这项技术，我们可以开始问有关以前从未提出过的真实3D细胞生物学的问题。”
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Featured image shows a microscopic structure for encapsulating cells made via Prellis holographic 3D bioprinting. Image via Prellis Biologics
