研究

纽约大学朝着溶解3D印刷骨植入物的临床试验发展

Scientists and surgeons atNYU School of MedicineandNYU College of Dentistry纽约,已经发表了一项研究,详细介绍了溶解骨骼治愈的3D印刷植入物。

According tothe study’s senior investigator Paulo Coelho, “Our 3D scaffold represents the best implant in development because of its ability to regenerate real bone,”

“Our latest study results move us closer to clinical trials and potential bone implants for children living with skull deformations since birth, as well as for veterans seeking to repair damaged limbs.”

Toward clinical testing

在NYU的3D印刷植入物可以用来治愈目前必须在活的动物模型中测试的人骨。

In this research, the team demonstrate that the implants can be used to regenerate bone across small holes in the skulls of mice and missing pieces of rabbits limbs and jaws, up to 1.2 cm long.

3D成像显示骨骼在6个月的时间内通过3D打印的植入物生长。在图像A. b,c中,骨骼是绿色的,植入物是紫色的。在d,e,f骨被染色粉红色,脚手架以黑色显示。图像通过组织工程和再生医学杂志
3D成像显示骨骼在6个月的时间内通过3D打印的植入物生长。在图像A. b,c中,骨骼是绿色的,植入物是紫色的。在d,e,f骨被染色粉红色,脚手架以黑色显示。图像通过组织工程和再生医学杂志

3D打印骨头

Bone implants in the NYU study are 3D printed to mimic the shape of a defective bone. For porosity, the artificial implants are designed as lattice structures (scaffolds), which also encourage new tissues to grown through them.

含有磷酸三氯的悬浮颗粒的凝胶(一种是天然骨的矿物)用作植入物的基本材料。该矿物质使植入物可以通过身体吸收。

A Carbon Black ink, which is washed away before implantation, is also used as support material, filling the circular center of the bone.

3D design of NYU's bone implants/scaffolds. Image via Journal of Tissue Engineering and Regenerative Medicine
3D design of NYU’s bone implants/scaffolds. Image via Journal of Tissue Engineering and Regenerative Medicine

最小化副作用

After 3D printing, the calcified implants are coated in dipyridamole, a blood thinning medication that prevents clotting, and also attracts bone stem cells. In the study, dipyridamole coating sped up bone formation by more than 50% when compared to non-coated samples.

该研究的合着者布鲁斯·诺斯坦(Bruce N.而且,由于植入物逐渐被吸收,因此该药物一次释放一点,并在局部释放到骨骼,而不是进入整个身体,从而最大程度地减少了异常的骨骼生长,出血或其他副作用的风险。”

下一步

The NYU team has a patent pending for the 3D printed scaffolds described in this study. The next step is to try the implants in larger animals, moving gradually toward future clinical trials.

目前正在进行研究的其他材料,以提高骨骼植入物的方式包括在内,丝绸PLA,nanodiamonds和3D绘制Shah-lab spinoff维度INX.

Form and Functional Repair of Long Bone Using 3D Printed Bioactive Scaffolds”在线发表在线Journal of Tissue Engineering and Regenerative Medicine.它是由Nick Tovar, Lukasz Witek, Pablo Atria, Michael Sobieraj, Michelle Bowers, Christopher Lopez, Bruce Cronstein, and Paulo G. Coelho.

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特色图像显示3D成像,显示骨骼在6个月的时间内通过3D印刷植入物生长。图像通过组织工程和再生医学杂志